Atithi Tum Kab Jaoge? is the story of Puneet and Munmun, a happily married couple living in Mumbai whose lives take an interesting turn when a distant relative, Chachaji turns up unannounced at their doorstep from a far off village. The guest overstays his welcome so much so that the exasperated couple come up with various ploys to hasten his departure to hilarious results.

Guddu and Charlie are identical twins born and raised in the slums of Mumbai. They dream of leaving the squalor behind and moving into a life of prosperity and dignity. Though they look alike, the two are as different as chalk and cheese: one lisps while the other stammers; one is an honest, diligent social worker while the other hedges bets at a racecourse. The brothers want nothing to do with each other, but when Charlie gets mixed up in a deadly get-rich-quick scheme and Guddu realizes that the love of his life has unwittingly put a price on his head, their lives begin to collide. Faced with rogue politicians, drug dealers and crooked cops, they uncover a sinister plot laid out by the 'political-police-underworld' nexus. Their stories finally converge to a point when they realize they only have each other.